Dosage and Administration
The recommended minimum dose is:
10 mg/kg body weight imidacloprid and 50 mg/kg body weight permethrin.
For dermal use only. Apply only to undamaged skin.
To reduce re-infestation from emergence of new fleas it is recommended that all dogs in a household be treated. Other pet animals living in the same household should also be treated with a suitable product. To further aid in reducing environmental challenge, the additional use of a suitable environmental treatment against adult fleas and their developmental stages is recommended.
The product remains effective if the animal becomes wet. However, prolonged, intense exposure to water should be avoided. In cases of frequent water exposure the persistent efficacy may be reduced. In these cases do not retreat more frequently than once weekly. If a dog requires a shampoo, it should be administered before applying Advantix or at least 2 weeks after application, to optimise efficacy of the product.
In case of biting louse infestation, a further veterinary examination 30 days after treatment is recommended as some animals may require a second treatment.
To protect a dog over the whole sand fly season, treatment should be compliantly continued throughout.

Method of Administration
Remove one pipette from the package. Hold pipette in an upright position, twist and pull cap off. Turn the cap around and place the other end of the cap back on the pipette. Twist cap to break seal, then remove cap from pipette.

Administration to Dogs Weighing 10kg or Less
With the dog standing still, part the coat between the shoulder blades until the skin is visible. Place the tip of the pipette on the skin and squeeze firmly several times to empty the contents directly onto the skin.

Administration to Dogs Weighing Over 10kg
With the dog standing still, the entire contents of the Advantix pipette(s) should be applied evenly to several spots on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. Place the tip of the pipette on the skin and gently squeeze to expel a portion of the solution onto the skin. Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run off the side of the dog. See Figure 3.

Contra-Indications, Warnings, etc
DO NOT USE ON CATS.
This product is extremely poisonous to cats and could be fatal due to the unique physiology of this species, which is unable to metabolise certain compounds, including permethrin. To prevent cats from being accidentally exposed to the product, keep cats away from treated dogs until the application site is dry. It is important to ensure that cats do not groom the site of application on a dog which has been treated with this product. Seek veterinary advice immediately if this occurs.
In the absence of available data, the product should not be used on puppies of less than 7 weeks of age or 1.5 kg of weight.
Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
Care should be taken to avoid the contents of the pipette coming into contact with the eyes or mouth of the recipient dogs.
Care should be taken to administer the product correctly as described under Method of Administration. In particular, oral uptake due to the licking of the application site by treated or in-contact animals should be avoided.
Consult your veterinary surgeon before using the product on sick and debilitated dogs.
On very rare occasions reactions in dogs may include transient skin sensitivity (increased local itching, scratching and rubbing, hair loss and redness at the application site) or lethargy that are generally self-resolving.
In very rare cases dogs may show behaviour changes (agitation, restlessness, whining or rolling), gastro-intestinal symptoms (vomiting, diarrhoea, hypersalivation, diminished appetite) and neurological signs such as unsteady movement and twitching in dogs susceptible to the ingredient permethrin. These signs are generally transient and self-resolving.
Poisoning following inadvertent oral uptake in dogs is unlikely but may occur in very rare cases. In this event, neurological signs such as tremor and lethargy can occur. Treatment should be symptomatic. There is no known specific antidote.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
There may be an attachment of single ticks, or bites by single sand flies or mosquitoes. For this reason, a transmission of infectious diseases by these parasites cannot be completely excluded if conditions are unfavourable.
It is recommended to apply the treatment at least 3 days before expected exposure to E. canis. With regard to E. canis, studies have demonstrated a reduced risk of canine ehrlichiosis in dogs exposed to Rhipicephalus sanguineus ticks infected with E. canis from 3 days following application of the product and to persist for 4 weeks.
No adverse clinical signs were noted in healthy puppies or adult dogs exposed to 5x overdosage or for puppies whose mothers were treated with 3x overdosage of the product.
As the product is dangerous to aquatic organisms, treated dogs must not under any circumstances be allowed into any type of surface water for at least 48 hours after treatment.
The solvent in Advantix Spot-on solution may stain certain materials including leather, fabrics, plastics and finished surfaces. Allow the application site to dry before permitting contact with such materials.

Use During Pregnancy and Lactation
The product may be used during pregnancy and lactation.