Advantage 40mg  for Small Dogs, Advantage 100 for Dogs, Advantage 250 for Dogs and Advantage 400 for Dogs are all clear yellow to slightly brownish solutions containing as active substance imidacloprid. Each tube contains 0.4 ml (40 mg imidacloprid), 1 ml (100 mg imidacloprid), 2.5 ml (250 mg imidacloprid) and 4.0 ml (400 mg imidacloprid) respectively plus benzyl alcohol and butylhydroxytoluene (E321) as an antioxidant.

Advantage for Dogs is used for the prevention and treatment of flea infestations and for the treatment of biting lice (Trichodectes canis) on dogs. Fleas are killed within one day following treatment. One treatment prevents further flea infestation for up to four weeks on dogs, treatment should be repeated after four weeks. Treatment of nursing bitches and queens controls flea infestations on both dam and offspring. Should re-treatment be necessary earlier than four weeks, do not treat more frequently than weekly.

Re-infestation from emergence of new fleas in the environment may continue to occur for six weeks or longer after treatment is initiated. More than one treatment may therefore be required, depending on the level of fleas in the environment. To aid reduction in environmental challenge, the additional use of a suitable environmental treatment against adult fleas and developing stages is recommended. In order to reduce further the environmental challenge, it is recommended that all cats, dogs and rabbits in the household are treated.

The product remains effective if the animal becomes wet, for example after exposure to heavy rain or after swimming (dogs). However, re-treatment may become necessary, depending on the presence of fleas in the environment. In these cases do not treat more frequently than once weekly. In the case of biting louse infection in dogs, a veterinary examination 30 days after treatment is recommended as some animals may require a second treatment.

Apply by removing one tube from the package. Hold the tube in an upright position, twist and pull off cap. Use reversed cap to twist and remove seal from tube. With the dog in the standing position, part the coat between the shoulder blades until the skin is visible. Place the tip of the tube on the skin and squeeze firmly several times to empty the contents directly onto the skin. The dog should be standing for easy application. The entire contents of the tube should be applied evenly to 3 or 4 spots all located at different application sites along the dog's back line from the shoulder to the base of the tail. At each spot, part the coat until the skin is visible. Place the tip of the tube on the skin and gently squeeze the tube to expel a portion of its contents directly onto the skin. Do not apply an excessive amount of solution at any one spot, as that could cause some of the product to run down the animals side. Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run down the side of the dog. The product is bitter tasting and salivation may occa­sionally occur if the dog licks the application site immediately after treatment. This is not a sign of intoxication and disappears within some minutes without treatment. Correct applica­tion will minimize the opportunity for the dog to lick the product. Apply only to undamaged skin. Do not allow recently treated animals to groom each other.

No reproductive toxic effects have been observed in rats and no primary embryotoxic or teratogenic toxic effects have been observed during the studies on rats and rabbits. Studies on pregnant and lactating bitches, queens and does together with their offspring are limited. Evidence so far indicates that no adverse effects are to be expected in these animals. Do not treat unweaned puppies of less than 8 weeks of age.